儿童传染性单核细胞增多症临床特征及T细胞亚群分析Analysis of clinical features and T lymphocyte subset in children with infectious mononucleosis
张坤龙;王会平;刘亢亢;汪燕;王宁玲;
摘要(Abstract):
目的探讨儿童传染性单核细胞增多症(IM)的临床特征和T细胞亚群变化规律,分析其临床意义。方法回顾性分析2015年1月-2016年12月收治的59例IM患儿的临床资料,比较患儿初诊及治疗后的临床特征和实验室检测指标。结果初诊患儿临床表现以发热(93.2%)、淋巴结肿大(62.7%)和咽峡炎(52.5%)多见;实验室检查以外周血WBC>10>10~9/L(84.7%)、外周血异型淋巴细胞>10%(81.3%)和ALT升高(52.5%)多见;与初诊时比较,治疗后淋巴结肿大阳性率差异无显著性(P>0.05),其他项目差异均具有显著性(P<0.05)。初诊患儿DNT细胞、CD3~+T细胞、CD3~+CD8~+T细胞百分比均显著高于对照组(P<0.01),CD3~+CD4~+T细胞百分比显著低于对照组(P<0.01)。治疗后患儿DNT细胞、CD3~+T细胞、CD3~+CD4~+T细胞、CD3~+CD8~+T细胞与正常对照组相比差异无显著性(P>0.05)。结论 IM起病时症状多样,存在明显的免疫失衡,监测患儿不同时期临床特点及T细胞亚群变化,能够为IM患儿临床免疫治疗提供理论依据。
关键词(KeyWords): 传染性单核细胞增多症,儿童;T细胞亚群
基金项目(Foundation):
作者(Author): 张坤龙;王会平;刘亢亢;汪燕;王宁玲;
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参考文献(References):
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