阿扎胞苷联合化疗桥接异基因造血干细胞移植治疗复发儿童母细胞性浆细胞样树突状细胞肿瘤1例
吴晓芳,陆叶,杨飞韵,何海龙,胡绍燕,李建琴,李捷
摘要(Abstract):
<正>1 病例资料患儿,男,6岁2月,因“发现右上臂肿物1月余”于2022年4月21日入院。患儿1月余前无明显诱因下发现右上臂青色肿物,约2cm×2cm大小,后逐渐增大,累及腋窝,无发热盗汗,无咳嗽咯痰,无消瘦等,2周前就诊于当地医院,右上肢核磁共振:右上臂内后方占位;右侧腋窝淋巴结肿大、融合。
关键词(KeyWords):
基金项目(Foundation):
作者(Author): 吴晓芳,陆叶,杨飞韵,何海龙,胡绍燕,李建琴,李捷
参考文献(References):
- [1] Arber DA,Orazi A,Hasserjian R,et al.The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia[J].Blood,2016,127:2391-2405.
- [2] Guru Murthy GS,Pemmaraju N,Atallah E.Epidemiology and survival of blastic plasmacytoid dendritic cell neoplasm[J].Leuk Res,2018,73:21-23.
- [3] Cuglievan B,Connors J,He J,et al.Blastic plasmacytoid dendritic cell neoplasm:A comprehensive review in pediatrics,adolescents,and young adults (AYA) and an update of novel therapies[J].Leukemia,2023,37:1767-1778.
- [4] Jain A,Sweet K.Blastic plasmacytoid dendritic cell neoplasm[J].J Natl Compr Canc Netw,2023,21:515-521.
- [5] Jegalian AG,Buxbaum NP,Facchetti F,et al.Blastic plasmacytoid dendritic cell neoplasm in children:Diagnostic features and clinical implications[J].Haematologica,2010,95:1873-1879.
- [6] Suzuki K,Suzuki Y,Hama A,et al.Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm[J].Leukemia,2017,31:1629-1633.
- [7] Pattabiraman DR,Gonda TJ.Role and potential for therapeutic targeting of MYB in leukemia[J].Leukemia,2013,27:269-277.
- [8] Abla D,Abboud MR,Noun D,et al.Hyper-CVAD combined with Venetoclax for relapsed pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN):A case report and literature review[J].Leuk Res Rep,2022,17:100313.
- [9] Trottier AM,Cerquozzi S,Owen CJ.Blastic plasmacytoid dendritic cell neoplasm:Challenges and future prospects[J].Blood Lymphat Cancer,2017,7:85-93.
- [10] Kim MJ,Nasr A,Kabir B,et al.Pediatric blastic plasmacytoid dendritic cell neoplasm:A systematic literature review[J].J Pediatr Hematol Oncol,2017,39:528-537.
- [11] Murthy HS,Zhang MJ,Chen K,et al.Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm:A CIBMTR analysis[J].Blood Adv,2023,7:7007-7016.
- [12] 朱会丽.儿童母细胞性浆细胞样树突细胞瘤1例诊治及移植后MRD转阳后相关治疗[J].中国小儿血液与肿瘤杂志,2022,27:127-128.
- [13] Montero J,Stephansky J,Cai T,et al.Blastic plasmacytoid dendritic cell neoplasm is dependent on BCL2 and sensitive to venetoclax[J].Cancer Discov,2017,7:156-164.
- [14] He J,Garcia MB,Connors JS,et al.Frontline Hyper-CVAD plus venetoclax for pediatric blastic plasmacytoid dendritic cell neoplasm[J].J Pediatr Hematol Oncol,2023,45:e1001-e1004.
- [15] Abla D,Abboud MR,Noun D,et al.Hyper-CVAD combined with Venetoclax for relapsed pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN):A case report and literature review[J].Leuk Res Rep,2022,17:100313.
- [16] Sapienza MR,Abate F,Melle F,et al.Blastic plasmacytoid dendritic cell neoplasm:Genomics mark epigenetic dysregulation as a primary therapeutic target[J].Haematologica,2019,104:729-737.
- [17] Laribi K,Denizon N,Ghnaya H,et al.Blastic plasmacytoid dendritic cell neoplasm:The first report of two cases treated by 5-azacytidine[J].Eur J Haematol,2014,93:81-85.
- [18] Sun W,Liu H,Kim Y,et al.First pediatric experience of SL-401,a CD123-targeted therapy,in patients with blastic plasmacytoid dendritic cell neoplasm:Report of three cases[J].J Hematol Oncol,2018,11:61.
- [19] Pemmaraju N,Cuglievan B,Lasky JL,et al.Treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in pediatric patients with tagraxofusp,a CD123-targeted therapy[J].Blood,2021,138 (Suppl 1):2317.